Two people were killed, and six others injured in an accident in rural Jackson County in Northeast Arkansas Tuesday that involved a total of 16 vehicles.

According to a preliminary report from the Arkansas State Police, all the vehicles were northbound on U.S. Highway 67 at approximately the 99-mile marker when they encountered heavy smoke from a nearby field fire that covered all four lanes of the highway.

As the vehicles entered the smoke, there was a chain reaction accident involving all 16 vehicles and they came to rest on or near the northbound traffic lanes.

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The two fatalities were in the same vehicle and the injured were taken to three different hospitals.

The accident was reported at 2:15 p.m. and the deaths bring to 424 the number of people killed on the state’s highways so far this year.